Calcium-calmodulin dependent protein kinase II (CaMKII): A main signal responsible for early reperfusion arrhythmias

► Early reperfusion arrhythmias are primarily dependent on CaMKII activation. ► DADs are a critical triggering mechanism of reperfusion arrhythmias. ► RyR2-Ser2814 is the main downstream target for CaMKII in reperfusion arrhythmias.