Arginylation regulates myofibrils to maintain heart function and prevent dilated cardiomyopathy

► New role of posttranslational arginylation in the heart muscle. ► New regulatory mechanism of myofibril maintenance and contractility. ► New insights into posttranslational regulation of the sarcomeric proteins. ► New correlation between cardiac myofibril forces, heart defects, and arginylation.