Systemic transplantation of allogenic fetal membrane-derived mesenchymal stem cells suppresses Th1 and Th17 T cell responses in experimental autoimmune myocarditis

► Experimental autoimmune myocarditis (EAM) is T cell-mediated disease. ► We have reported that fetal membrane (FM)-derived MSCs ameliorate EAM. ► We examine T cell differentiation in FM-MSC-administered EAM rats. ► FM-MSCs attenuate EAM via suppression of Th1 and Th17 immunity. ► Cultured FM-MSCs reduce Th1/Th17 cell-differentiation and proliferation.