PKA phosphorylation of cardiac ryanodine receptor modulates SR luminal Ca2+ sensitivity

► PKA-phosphorylation of RyR2-S2808 is involved in Ca2+ release synchronization. ► RyR2-S2808 phosphorylation promotes Ca2+ wave acceleration. ► SR luminal Ca2+ sensing is reduced in unphosphorylatable RyR2-S2808A channels.