Role of PI3Kα and sarcolemmal ATP-sensitive potassium channels in epoxyeicosatrienoic acid mediated cardioprotection

► Involves activation of the PI3Kα isoform ► PI3Kα is upstream of ATP-sensitive K + (KATP) channel activation. ► Limits calcineurin activity and subsequent apoptotic events. ► Preserves mitochondrial function.