Improvement of left ventricular diastolic function induced by β-blockade

► β-blockade improves of left ventricular diastolic and coronary dysfunctions in rats with metabolic syndrome. ► Enhanced NO bio-availability is involved in the improvement of LV diastolic dysfunction by β-blockers. ► Both coronary endothelial and LV diastolic dysfunctions observed in metabolic syndrome are improved by β-blockade.