Paclitaxel accelerates spontaneous calcium oscillations in cardiomyocytes by interacting with NCS-1 and the InsP3R

►Paclitaxel accelerates calcium oscillations in cardiomyocytes. ►Paclitaxel binds to neuronal calcium sensor 1 (NCS-1). ►NCS-1 enhances the activity of the InsP3R. ►The extra InsP3R activity modulates the calcium oscillation frequency. ►The effects of paclitataxel in cardiomyocytes is opposite that seen in neurons.