Critical role for white blood cell NAD(P)H oxidase-mediated plasminogen activator inhibitor-1 oxidation and ventricular rupture following acute myocardial infarction

► PAI-1 has a critical role in left ventricular remodeling following acute myocardial infarction. ► PAI-1 is activity is susceptible to oxidation in the inflammatory milieu. ► NADPH oxidase, not myeloperoxidase- or iNOS-mediated oxidation, is critical in PAI-1 inactivation.