Endoplasmic reticulum chaperon tauroursodeoxycholic acid alleviates obesity-induced myocardial contractile dysfunction

►The ER chaperone tauroursodeoxycholic acid (TUDCA) alleviates obesity-induced ER stress and myocardial contractile dysfunction. ►TUDCA reconciles obesity-induced increase in diastolic diameter, cardiac hypertrophy, compromised fractional shortening, cardiomyocyte contractile and intracellular Ca2+ properties. ►TUDCA ablated palmitic acid-induced cardiomyocyte contractile dysfunction.