کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10954407 | 1097902 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Sarcolemmal KATP channels: what do we really know?
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
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چکیده انگلیسی
KATP channels are present at an extremely high density in the heart, and we know from in vitro studies that channel activation causes dramatic action potential shortening and contractile failure. But, if and when this happens in vivo is still a matter of debate. Twenty one years of intense study have led to a well-developed understanding of the molecular basis of KATP channel activity. Structure-function studies, together with cellular experiments probing regulatory molecules have told us much about the way the KATP channel can activate, and gene-targeting and proteomic tools have further elucidated determinants of in vivo function. However, the true physiological determinants of sarcolemmal KATP activity remain elusive, we still await full illumination of the role of the channel in the intact heart.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular and Cellular Cardiology - Volume 39, Issue 1, July 2005, Pages 61-70
Journal: Journal of Molecular and Cellular Cardiology - Volume 39, Issue 1, July 2005, Pages 61-70
نویسندگان
Thomas P. Ph.D., Colin G. Ph.D.,