کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10954520 | 1097909 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Roles of KATP channels as metabolic sensors in acute metabolic changes
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
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چکیده انگلیسی
Physiological and pathophysiological roles of KATP channels have been clarified recently in genetically engineered mice. The Kir6.2-containing KATP channels in pancreatic Ã-cells and the hypothalamus are essential in the regulation of glucose-induced insulin secretion and hypoglycemia-induced glucagon secretion, respectively, and are involved in glucose uptake in skeletal muscles, thus playing a key role in the maintenance of glucose homeostasis. Disruption of Kir6.1-containing KATP channels in mice leads to spontaneous vascular spasm mimicking vasospastic (Prinzmetal) angina in humans, indicating that the Kir6.1-containing KATP channels in vascular smooth muscles participate in the regulation of vascular tonus, especially in coronary arteries. Together with protective roles of KATP channels against cardiac ischemia and hypoxia-induced seizure propagation, it is now clear that KATP channels, as metabolic sensors, are critical in the maintenance of homeostasis against acute metabolic changes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular and Cellular Cardiology - Volume 38, Issue 6, June 2005, Pages 917-925
Journal: Journal of Molecular and Cellular Cardiology - Volume 38, Issue 6, June 2005, Pages 917-925
نویسندگان
Takashi Miki, Susumu Seino,