Involvement of the ANGPTs/Tie-2 system in ovarian hyperstimulation syndrome (OHSS)

► ANGPT1 was increased in FF and in granulosa-lutein cells from OHSS patients. ► Incubation of FF with an ANGPT1 inhibitor decreased endothelial cell migration. ► In the OHSS rat model, mTie-2 protein levels increased and PDGF-B and -D decreased. ► These results show a greater biological activity of ANGPTs/Tie-2 system in OHSS. ► PDGF-B and -D levels could be linked with the increased permeability in OHSS.