Investigation of peripubertal expression of Lin28a and Lin28b in C57BL/6 female mice

► Expression of Lin28a and Lin28b decreases in the ovary prior to pubertal onset. ► Expression of Lin28a decreases in the hypothalamus prior to the onset of puberty. ► A decrease Lin28a protein levels mirrored the decline in Lin28a in ovarian tissue. ► Lin28 regulation of pubertal onset may occur at the ovarian and hypothalamic level. ► The effects of the Lin28 pathway may be mediated, in part, independently of Let-7.