Separate regions of glucocorticoid receptor, coactivator TIF2, and comodulator STAMP modify different parameters of glucocorticoid-mediated gene induction

► Differential control of steroid-regulated induction by varying Amax, EC50, and PAA. ► Control of Amax, EC50, and PAA can occur via separate pathways/molecular interactions. ► Different cofactor domains influence the three different induction parameters. ► Independent modulation of Amax, EC50, and PAA of exogenous and endogenous genes.