Selective liver X receptor modulators (SLiMs): What use in human health?

► LXR are members of the nuclear receptor superfamily. ► Numerous natural and synthetic molecules could module LXR activity. ► LXR are promising pharmacological targets in human diseases. ► Atherosclerosis, diabetes, Alzheimer, skin disorders, and cancers could be targeted. ► Development of selective liver X modulators (SLiMs) is a challenge.