SMRTε, a corepressor variant, interacts with a restricted subset of nuclear receptors, including the retinoic acid receptors α and β

► SMRTε is an alternatively-spliced form of corepressor. ► SMRTε expression differs in different cell types. ► SMRTε displays a restricted specificity for a subset of nuclear receptor partners. ► SMRTε interacts with nuclear receptors by a mix of α-helical and β-strand surfaces. ► SMRTε is highly specific for RARs when bound to their cognate DNA response elements.