CCK receptors-related signaling involved in nitric oxide production caused by gastrin 17 in porcine coronary endothelial cells

► Gastrin 17 dose-dependently increase NO production in coronary endothelial cells. ► Both CCK1 and CCK2 subtypes receptors are involved in gastrin 17 effects. ► PKA and, slightly, PKC are the downstream effectors of CCK receptors activation. ► eNOS activation by gastrin 17 is dependent on ERK, Akt and p38 phosphorylation.