کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10956286 | 1098823 | 2012 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Catechol-O-methyltransferase (COMT) single nucleotide polymorphisms and haplotypes are not major risk factors for polycystic ovary syndrome
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Catechol-O-methyltransferase (COMT) single nucleotide polymorphisms and haplotypes are not major risk factors for polycystic ovary syndrome Catechol-O-methyltransferase (COMT) single nucleotide polymorphisms and haplotypes are not major risk factors for polycystic ovary syndrome](/preview/png/10956286.png)
چکیده انگلیسی
⺠Catechol-O-methyltransferase gene (COMT) variants are not significantly associated with polycystic ovary syndrome. ⺠No significant correlations between COMT genotypes and total testosterone, non-SHBG bound testosterone and BMI were found. ⺠COMT haplotypes associated with reduced enzyme activity were associated with higher prolactin levels in PCOS women. ⺠COMT haplotypes associated with higher enzyme activity were associated with lower prolactin levels. ⺠Significant associations between COMT haplotypes and prolactin may reflect a role of COMT variation in the stress response.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Cellular Endocrinology - Volume 350, Issue 1, 5 March 2012, Pages 72-77
Journal: Molecular and Cellular Endocrinology - Volume 350, Issue 1, 5 March 2012, Pages 72-77
نویسندگان
Lori D. Hill, Kathryn G. Ewens, Brion S. Maher, Timothy P. York, Richard S. Legro, Andrea Dunaif, Jerome F. III,