Androgen regulated HN1 leads proteosomal degradation of androgen receptor (AR) and negatively influences AR mediated transactivation in prostate cells

► HN1 is an androgen regulated gene. ► Its expression promotes cytoplasmic retention of AR in LNCaP cells. ► HN1 overexpression increases proteosomal degradation of AR. ► HN1 influences androgen-mediated growth in LNCaP cells. ► HN1 also increases migration in androgen independent PC-3 and DU145 cells.