Molecular dynamics of ultradian glucocorticoid receptor action

► This review focuses on the highly dynamic mode of GR action at the chromatin template. ► Stochastic GR action is discussed in light of the glucocorticoid ultradian rhythm. ► GR slow cycling on chromatin is directed by the pulsatile ligand. ► GR slow cycling directs a novel gene pulsing effect. ► Cyclical activity of cofactors and histone acetylation at a GR regulated gene.