Structural basis for nuclear hormone receptor DNA binding

► All nuclear receptors bind monomeric or dimeric 5′-AGAACA-3′ or 5′-AGGTCA-3′ hexamers. ► High throughput definition of binding sites confirm the classical DNA binding rules. ► Dimerization of steroid receptors on DNA is asymmetrical. ► The DNA sequence can control a nuclear receptor through allosteric signaling.