Structural and functional analysis of domains of the progesterone receptor

► This paper reviews the structural dynamics of steroid hormone receptors. ► The hinge region and amino-terminal domain (NTD) are intrinsically disordered regions of receptors. ► The hinge and NTD form multiple conformations upon binding co-regulatory proteins or DNA. ► Due to structural flexibility, the hinge and NTD are sites of post-translation modifications.