Adiponectin upregulates hepatocyte CMKLR1 which is reduced in human fatty liver

► Chemokine-like receptor 1 (CMKLR1) is the receptor for the adipokine chemerin. ► CMKLR1 is expressed by hepatocytes. ► CMKLR1 is reduced in fatty liver and in rodent fibrotic liver. ► Adiponectin induces CMKLR1 in hepatocytes. ► CMKLR1 is reduced in liver of adiponectin-deficient mice.