کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10956661 | 1099394 | 2011 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Sphingosine 1-phosphate receptor modulator fingolimod (FTY720) does not promote remyelination in vivo
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Sphingosine 1-phosphate receptor modulator fingolimod (FTY720) does not promote remyelination in vivo Sphingosine 1-phosphate receptor modulator fingolimod (FTY720) does not promote remyelination in vivo](/preview/png/10956661.png)
چکیده انگلیسی
The sphingosine 1-phosphate (S1P) receptor modulators have emerged as a new therapeutic opportunity paradigm for the treatment of immune-mediated demyelinating diseases such as multiple sclerosis (MS). The S1P analog fingolimod (FTY720) has been shown to alleviate disease burden in immune-mediated animal models of MS, and has been approved for treatment in clinical trials in patients with MS in the United States. While the immunological effects of FTY720 are well established, there is controversy in the literature regarding the contribution of FTY720 on myelin repair. Here, we directly assessed the impact of FTY720 on myelin repair in cuprizone and lysolecithin (LPC) demyelination models that have a minimal immunological component. FTY720 failed to promote remyelination in either animal model. These studies suggest that while FTY720 may be effective at modulating the immunological attack in MS, it may benefit from an add-on therapy to enhance the myelin repair required for long-term functional restoration in MS.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Cellular Neuroscience - Volume 48, Issue 1, September 2011, Pages 72-81
Journal: Molecular and Cellular Neuroscience - Volume 48, Issue 1, September 2011, Pages 72-81
نویسندگان
Yinghui Hu, Xinhua Lee, Benxiu Ji, Kevin Guckian, Daniel Apicco, R. Blake Pepinsky, Robert H. Miller, Sha Mi,