کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10956703 | 1099404 | 2010 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Modulation of Cav1.3 Ca2+ channel gating by Rab3 interacting molecule
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Modulation of Cav1.3 Ca2+ channel gating by Rab3 interacting molecule Modulation of Cav1.3 Ca2+ channel gating by Rab3 interacting molecule](/preview/png/10956703.png)
چکیده انگلیسی
Neurotransmitter release and spontaneous action potentials during cochlear inner hair cell (IHC) development depend on the activity of Cav1.3 voltage-gated L-type Ca2+ channels. Their voltage- and Ca2+-dependent inactivation kinetics are slower than in other tissues but the underlying molecular mechanisms are not yet understood. We found that Rab3-interacting molecule-2α (RIM2α) mRNA is expressed in immature cochlear IHCs and the protein co-localizes with Cav1.3 in the same presynaptic compartment of IHCs. Expression of RIM proteins in tsA-201 cells revealed binding to the β-subunit of the channel complex and RIM-induced slowing of both Ca2+- and voltage-dependent inactivation of Cav1.3 channels. By inhibiting inactivation, RIM induced a non-inactivating current component typical for IHC Cav1.3 currents which should allow these channels to carry a substantial window current during prolonged depolarizations. These data suggest that RIM2 contributes to the stabilization of Cav1.3 gating kinetics in immature IHCs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Cellular Neuroscience - Volume 44, Issue 3, July 2010, Pages 246-259
Journal: Molecular and Cellular Neuroscience - Volume 44, Issue 3, July 2010, Pages 246-259
نویسندگان
Mathias Gebhart, Gabriella Juhasz-Vedres, Annalisa Zuccotti, Niels Brandt, Jutta Engel, Alexander Trockenbacher, Gurjot Kaur, Gerald J. Obermair, Marlies Knipper, Alexandra Koschak, Jörg Striessnig,