کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10956776 | 1099455 | 2005 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Assembly of the N-cadherin complex during synapse formation involves uncoupling of p120-catenin and association with presenilin 1
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Assembly of the N-cadherin complex during synapse formation involves uncoupling of p120-catenin and association with presenilin 1 Assembly of the N-cadherin complex during synapse formation involves uncoupling of p120-catenin and association with presenilin 1](/preview/png/10956776.png)
چکیده انگلیسی
N-cadherin is an adhesion receptor that participates in both interaction between immature pre- and postsynaptic neurons and in the stabilization and function of matured neuron-neuron synapses. To better understand how the N-cadherin complex contributes to synapse formation, we examined its distribution and composition during synapse formation in the chick ciliary neurons. It was found that at early phases of synaptogenesis, N-cadherin is distributed in small clusters on the cell surface and primarily associates with p120-catenin and β-catenin. In contrast, as synaptic contacts matured, larger N-cadherin clusters were found localized adjacent to the active zone and associated with PS1 and γ-catenin, while p120- and β-catenin were dispersed among other cell regions, including axons. As it is known that PS1 binds γ-catenin and that uncoupled p120-catenin can alter the cytoskeleton via its effect on Rho GTPases, these changes in the molecular composition of the N-cadherin complex (represented by the uncoupling of p120-catenin and association with PS1) may correspond to distinct functional states of the complex involved in synaptic maturation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Cellular Neuroscience - Volume 30, Issue 1, September 2005, Pages 118-130
Journal: Molecular and Cellular Neuroscience - Volume 30, Issue 1, September 2005, Pages 118-130
نویسندگان
Maria E. Rubio, Christine Curcio, Norbert Chauvet, Juan L. Brusés,