کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10957696 1099600 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A novel peptide-based recognition probe for the sensitive detection of CD44 on breast cancer stem cells
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
A novel peptide-based recognition probe for the sensitive detection of CD44 on breast cancer stem cells
چکیده انگلیسی
Metastasis and recurrence of breast cancer remain significant clinical problems. The expression level of CD44 protein is higher in breast cancer-initiating cancer stem cells; therefore, the early detection of CD44 using a sensitive diagnostic probe is important for breast cancer diagnosis and therapeutic purposes. In this study, we fabricated a polyvalent directed peptide polymer (PDPP) that specifically recognized the CD44 biomarker, as confirmed by immunocytochemistry tests and fluorescence-activated cell sorting assessment. Our results indicate that PDPP is useful as a novel tool for the sensitive detection of breast cancer stem cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Cellular Probes - Volume 29, Issue 6, December 2015, Pages 492-499
نویسندگان
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