Development of a pattern in biochemical parameters in the core and penumbra during infarct evolution after transient MCAO in rats

► Core and penumbra differ in biochemical parameters. ► Parameters clearly reflect spreading of tissue damage after MCAO. ► Patterns seem to be clearly established on the first day after MCAO. ► Difference in SOD and translation activity could be observed 1 day of reperfusion. ► 1 day reperfusion is a breakpoint-time at which process of apoptosis is reversible.