Vitamins K interact with N-terminus α-synuclein and modulate the protein fibrillization in vitro. Exploring the interaction between quinones and α-synuclein

► Vitamins K interact with N-terminus α-syn and modulate protein fibrillization. ► Interaction of α-syn with vitamins K produces short and sheared fibrils. ► The 1,4-NQ is a potential scaffold to develop drugs targeting α-syn fibrillization.