Glutamate oxidative injury to RGC-5 cells in culture is necrostatin sensitive and blunted by a hydrogen sulfide (H2S)-releasing derivative of aspirin (ACS14)

► Aspirin derivative (ACS14) that releases hydrogen sulphide is a powerful neuroprotectant. ► Aspirin is a very weak neuroprotectant. ► Glutamate-induced oxidative death to cells is necrostatin sensitive. ► Apoptosis inducing factor in cells unaffected by glutamate-induced oxidative stress.