Antidepressant-like effect of a Ginkgo biloba extract (EGb761) in the mouse forced swimming test: Role of oxidative stress

► EGb761 produces antidepressant-like effect in the forced swimming test. ► Protection by EGb761 is not related to excitatory or inhibitory effects. ► Antidepressant-like effect is associated to a reduction of lipid peroxidation. ► Protection is also related to a downregulation of Mn-superoxide dismutase activity. ► EGb761 has antioxidant effect against oxidative stress in this animal model.