Amyloid-β induced toxicity involves ganglioside expression and is sensitive to GM1 neuroprotective action

► Aβ25-35 affected ganglioside expression in organotypic hippocampal cultures. ► Fibrillar Aβ25-35 increased GM3 labeling and reduced GD1b labeling. ► Non-fibrillar form of Aβ25-35 enhanced GM1 expression. ► Gangliosides could participate in the development of Alzheimer's disease. ► GM1 exhibited a neuroprotective effect against Aβ-induced toxicity in organotypic model.