Effects of a new synthetic butyrylcholinesterase inhibitor, HBU-39, on cell proliferation and neuroblast differentiation in the hippocampal dentate gyrus in a scopolamine-induced amnesia animal model

► A synthetic compound, HBU-39, potently inhibited butyrylcholinesterase. ► Scopolamine-induced amnesia showed significant reduction in neurogenesis. ► HBU-39 strongly ameliorated the reduction of neurogenesis induced by scopolamine.