Norepinephrine transporter (NET) knock-out upregulates dopamine and serotonin transporters in the mouse brain

► We show the noradrenaline, serotonin and dopamine transporters in the brain of NET-KO mice. ► Up-regulation of DAT and SERT in most of brain regions of the NET-KO mice, as compared to WT mice. ► Lack of differences at the level of mRNA encoding SERT and DAT between NET-KO and WT mice. ► Results point to important adaptive changes induced by life-long knock-out of NET.