Neuroprotective effect of neuroserpin in rat primary cortical cultures after oxygen and glucose deprivation and tPA

▶ Neuroserpin reduces ischemia-induced cell death in rat cortical cultures. ▶ Treatment with tPA after OGD increases LDH release, active MMP-9, MCP-1 and MIP-2. ▶ Neuroserpin treatment attenuates tPA-mediated deleterious mechanisms after ischemia.