Down-regulation of glutamine synthetase enhances migration of rat astrocytes after in vitro injury

▶ Down-regulation of glutamine synthetase (GS) in astrocytes at early stage at injury site induces astrocytes migration after injury. ▶ Down-regulation of GS impairs the attachment and spreading of astrocytes. ▶ Metalloproteinases involve in GS mediated astrocytes migration. ▶ Integrin β1 involves in GS mediated astrocytes process extension after wound.