Zinc-mediated attenuation of hippocampal mossy fiber long-term potentiation induced by forskolin

▶ Forskolin-induced mossy fiber LTP was attenuated by 100 μM Zn pre-perfusion. ▶ The zinc pre-perfusion did not attenuate Sp-cAMPS-induced mossy fiber LTP. ▶ Zinc may attenuate mossy fiber LTP via inhibition of adenylyl cyclase activity.