Calcium regulates the mode of exocytosis induced by hypotonic shock in isolated neuronal presynaptic endings

Thus, our data suggest that hypotonic swelling induces calcium-independent exocytosis possibly by a “kiss and run” mechanism. Calcium influx mediated by stretch channels is able to provoke full fusion between plasma membrane and synaptic vesicles. [3H]d-aspartate and [3H]GABA released by hypotonic shock is determined by sodium lowering rather than by osmolarity decreasing itself.