Regulation of cell migration by dynamic microtubules

► Microtubule-dependent regulation of cell migration is particularly important in large cells. ► Microtubules transport post-Golgi carriers, mRNA and recycling endosomes to cortical locations. ► Microtubules regulate actin assembly kinetics and focal adhesion turnover. ► Microtubule functions in cell migration require proper regulation of microtubule dynamics. ► Changes in microtubule dynamics affect cell migration through multiple pathways.