Bone Morphogenetic Protein functions as a context-dependent angiogenic cue in vertebrates

► The Bone Morphogenetic Protein (BMP) is one of the key regulatory molecules modulating embyogenesis, including vascular development. ► However, there is no general consensus on the function of BMP signaling during vascular development due to conflicting evidences supporting both ► pro- and anti-angiogenic functions of BMP signaling. ► Here, we reviewed recent literature to provide more comprehensive understanding on the function of BMP signal during vascular development.