Neuronal action on the developing blood vessel pattern

► Neural tube-derived signals regulate sprouting capillaries to form a stereotypic vessel ingression pattern. ► Neural tube-derived signals induce blood brain barrier characteristics in the neural tube vasculature. ► Peripheral nerve-derived signals direct arterial differentiation in the developing limb skin. ► Peripheral nerve-derived signals regulate patterns of angiogenic remodeling to establish nerve-artery alignment.