Post-translational modification of 14-3-3 isoforms and regulation of cellular function

► Dimeric 14-3-3 isoforms modulate protein interactions in a wide range of functions. ► 14-3-3s interact with over 200 protein kinases, phosphatases and other signalling proteins. ► Association usually involves phosphorylation of the interactor on novel phosphoserine motifs. ► Phosphorylation and other modifications of 14-3-3 itself may also modulate interaction. ► Acetylation of lysines or acylation of both 14-3-3 and its targets can also affect interaction.