Interactions between subunits of the Mediator complex with gene-specific transcription factors

► The Mediator complex forms the bridge between transcription factors and RNAP II. ► Tissue-specific transcription factors interact with specific Mediator subunits. ► Activator binding induces a conformational change within the Mediator complex. ► Mediator coordinates RNAP II recruitment, phosphorylation and postinitiation events.