Mediator and human disease

► Mediator subunits are associated with human developmental defects. ► Neurodevelopmental and behavioral disorders has been linked to Mediator. ► Dysregulation of Mediator subunits are linked to cancer development and progression. ► Mediator kinase module is implicated in both cancer and neuropsychiatric illness. ► Mediator is potential therapeutic target for a range of human pathologies.