کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10959305 1100426 2007 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Packing of the polynucleosome chain in interphase chromosomes: Evidence for a contribution of crowding and entropic forces
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Packing of the polynucleosome chain in interphase chromosomes: Evidence for a contribution of crowding and entropic forces
چکیده انگلیسی
In the crowded intranuclear environment, entropic depletion forces between macromolecules are expected to be strong. A review of simulations of linear polymers leads to several predictions about probable conformations of a polynucleosome chain in these conditions. These include a globular conformation, variable compaction due to different local rigidity or curvature of the mosaic of isochores, satellite sequences, and nucleosomes containing different histone variants, and the possibility that chromosomes represent separate phases like those seen in heterogeneous particle mixtures by experiment and simulation. Experimental results which show that macromolecular crowding alone, in the absence of exogenous cations, can stabilise interphase chromosomes and cause self-association of polynucleosome chains are presented. Together, these considerations suggest that macromolecular crowding and entropic forces are major factors in packing polynucleosome chains in vivo.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Cell & Developmental Biology - Volume 18, Issue 5, October 2007, Pages 668-675
نویسندگان
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