Reiterated Wnt and BMP signals in neural crest development

Common signaling pathways such as those for Wnts and BMPs are used many times during embryogenesis. During the development of the neural crest, Wnt and BMP signals are used repeatedly at different stages to influence initial induction, segregation from the neuroepithelium and cell fate determination. This review considers how specificity is generated within the neural crest for these reiterated signals, discussing examples of how the outcomes of signaling events are modulated by context.