Plasma concentrations of transdermal fentanyl and buprenorphine in pigs (Sus scrofa domesticus)

A relevant serum concentration obtained with fentanyl TP dosed at 75 μg hour−1 or 100 μg hour−1suggests that TPs could represent an analgesia option for laboratory pigs weighing 25-30 kg. As concentrations of buprenorphine were variable, this study does not support the use of buprenorphine TPs in pigs. Consecutive fentanyl or buprenorphine TPs did not provide reliable serum concentrations. Further pharmacokinetic studies and analgesiometric tests in swine are needed to confirm the clinical adequacy of TPs.