Effects of acepromazine-morphine and acepromazine-methadone premedication on the minimum alveolar concentration of isoflurane in dogs

The percentage reduction of the ISOMAC in ACPMET was approximately twice that in ACPMOR. Premedication with acepromazine-morphine or acepromazine-methadone increased the incidence of bradycardia. Hypotension was observed in most dogs during isoflurane anesthesia regardless of premedication.