The disposition and behavioral effects of methadone in Greyhounds

Methadone was well tolerated by Greyhounds. The volume of distribution was larger than expected, with resultant lower plasma concentrations than expected. Higher doses may need to be administered to Greyhounds in comparison with non-Greyhound dogs in order to achieve similar plasma drug concentrations. A dosage of 1-1.5 mg kg−1 every 3-4 hours is suggested for future studies of analgesic efficacy of methadone in Greyhounds.