Keywords: حجم توزیع; 11βHSD; 11β-Hydroxysteroid dehydrogenase; ABC; ATP-binding cassette; AhR; aryl hydrocarbon receptor; ARNT; aryl hydrocarbon receptor nuclear translocator; BCRP; breast cancer resistance protein; CAR; constitutive androstane receptor; CYP; cytochrome P45
مقالات ISI حجم توزیع (ترجمه نشده)
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در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
Keywords: حجم توزیع; pKa; High throughput; Ionization; Volume of distribution; PBPK;
Keywords: حجم توزیع; AM; alveolar macrophage; cAM; alveolar macrophage count (= TCC x AM); cPMN; polymorphonuclear neutrophil count (TCC x PMN); BAL; bronchoalveolar lavage; BET; Brunauer-Emmett-Teller; BMCL; benchmark concentration lower confidence limit; GSD; geometric stan
Keywords: حجم توزیع; AUC; area under the concentration-time curve; AST; aspartate transaminase; ALT; alanine transaminase; BCRP; breast cancer resistance protein; BEI; biliary excretion index; CL/F; oral clearance; Clbiliary; in vitro biliary clearance; ER; Efflux Ratio; LCâ
Keywords: حجم توزیع; ADAM; advanced dissolution, absorption, and metabolism; AED; antiepileptic drug; AUC; area-under-the-curve; B/P; blood to plasma ratio; BID; twice daily; BMI; body mass index; CBZ; carbamazepine; CLint; intrinsic clearance; CLR; renal clearance; CL; clear
Keywords: حجم توزیع; Convection-enhanced delivery; Volume of distribution; Nanoparticle; Otsu's method;
Keywords: حجم توزیع; pharmacokinetics; maintenance dose; loading dose; maturation; CL; Clearance; GA; Gestational age; PNA; Postnatal age; V; Volume of distribution;
Keywords: حجم توزیع; Cmax; extrapolated maximum concentration immediately after the end of the infusion; Cmin; extrapolated minimum concentration immediately after the end of the infusion; Cl; clearance (L/h); CrCl; creatinine clearance; GFR; glomerular filtration rate; T1/2;
Keywords: حجم توزیع; Baicalin; Baicalein; Flavonoids; Chemoprevention; Inflammatory diseases; 6-OHDA; 6-hydroxydopamine; 12-LOX; 12-lipoxygenase; AIDS; acquired immunodeficiency disorder syndrome; AhR; aryl hydrocarbon receptor; AIH; autoimmune hepatitis; AICAR; 5-aminoimidaz
Keywords: حجم توزیع; Contraceptive drugs; Pharmacokinetics; Obesity; Clearance; Volume of distribution; Model-fitting;
Keywords: حجم توزیع; AUC24; area under the concentration time curve in 24Â h; CL; clearance; Cmax; maximum concentration; Cmin; minimum concentration; FN; febrile neutropenia; Ke; elimination rate-constant; MIC; minimal inhibitory concentration; SD; standard deviation; t1/2;
Keywords: حجم توزیع; Brain; Convection-enhanced delivery; Drug-delivery system; MRI test infusion; CED; Convection-enhanced delivery; CSF; Cerebrospinal fluid; CT; Computed tomography; FLAIR; Fluid-attenuated inversion recovery; GBM; Glioblastoma multiforme; Gd-DTPA; Gadolini
Keywords: حجم توزیع; cefazolin; pharmacokinetics; perioperative; NONMEN; perioperative prophylaxis; CL; clearance; CPB; cardiopulmonary bypass; PAP; perioperative antibiotic prophylaxis; SSI; surgical site infection; STS; Society of Thoracic Surgeons; Vd; volume of distributi
Keywords: حجم توزیع; AUC; area under the curve; BZD; benzodiazepine; Cl; total clearance; Cmax; peak concentration; CNS; central nervous system; DOPAC; 3,4-dihydroxyphenylacetic acid; DZP; diazepam; GABA; γ-aminobutyric acid; EEG; electroencephalogram;; f; respiratory freque
Keywords: حجم توزیع; Extracellular fluid; fluid balance; fluid compartments; intracellular fluid; ion composition; sodium homeostasis; volume homeostasis; volume of distribution
Keywords: حجم توزیع; AFFF; aqueous film fire-fighting foams; C; concentration of a PFAA in serum; D; daily intake dose; kP; first order elimination rate; NHANES; National Health and Nutritional Evaluation Survey; PFAA; perfluorinated alkyl acid; PFBA; perfluorobutanoic acid;
Keywords: حجم توزیع; Azithromycin; Macrolide antibiotic; Mechanisms of action; Pharmacokinetics; Immunomodulation; Clinical efficacy; AECOPD; acute exacerbations of COPD; AP-1; activator protein-1; ARDS; acute respiratory distress syndrome; AUC; area under the plasma concentr
Keywords: حجم توزیع; ADME; DMPK; disposition; distribution; partition coefficients; pharmacokinetics; tissue distribution; toxicology; volume of distribution; safety assessment;
Design and synthesis of a biaryl series as inhibitors for the bromodomains of CBP/P300
Keywords: حجم توزیع; Bromodomain; CBP inhibitor; Volume of distribution; Half-life;
In vivo and in vitro diclofenac 5-hydroxylation mediated primarily by cytochrome P450 3A enzymes in common marmoset livers genotyped for P450 2C19 variants
Keywords: حجم توزیع; AUC; area under the plasma concentration vs. time curve; CL; total body clearance; P450; general term for cytochrome P450 (EC 1.14.14.1); V; volume of distribution; Marmoset; CYP3A4; CYP2C19; Polymorphism; PBPK;
Use of biorelevant dissolution and PBPK modeling to predict oral drug absorption
Keywords: حجم توزیع; Biorelevant dissolution; Weak base; PBPK modeling; BCS class II; pH dependent solubility; ACAT; advanced compartmental absorption and transit model; ADAM; advanced dissolution, absorption and metabolism model; API; active pharmaceutical ingredient; ASD;
Comprehensive assessment of Cucurbitacin E related hepatotoxicity and drug-drug interactions involving CYP3A and P-glycoprotein
Keywords: حجم توزیع; Cucurbitacin E; CYP3A; P-glycoprotein; Hepatotoxicity; Drug-drug interactions; CuE; cucurbitacin E; P-gp; p-glycoprotein; Cmax; the maximum serum concentration; AUC; area under the concentration-time curve; CL; clearance; Vd; volume of distribution; t1/2;
Pharmacokinetics, pharmacodynamics and safety profiling of IS01957, a preclinical candidate possessing dual activity against inflammation and nociception
Keywords: حجم توزیع; Pharmacokinetics; Inflammation; Nociception; Safety pharmacology; IS01957; Para-coumaric acid derivative; p-CA; Para coumaric acid; ADME; Absorption, distribution, metabolism and excretion; CH; Chlorpromazine hydrochloride; PS; Pentobarbital sodium; PBS;
IMI - oral biopharmaceutics tools project - evaluation of bottom-up PBPK prediction success part 1: Characterisation of the OrBiTo database of compounds
Keywords: حجم توزیع; API; active pharmaceutical ingredient; AUC; area under the curve; BCS; biopharmaceutics classification system; BP; blood-to-plasma ratio; Cmax; maximum concentration; CL; clearance; Do; dose number according to BCS; DDI; drug-drug interaction; EFPIA; Euro
IMI - Oral biopharmaceutics tools project - Evaluation of bottom-up PBPK prediction success part 3: Identifying gaps in system parameters by analysing In Silico performance across different compound classes
Keywords: حجم توزیع; AFE; Average Fold Error; AAFE; Absolute Average Fold Error; API; Active pharmaceutical ingredient; AUC; Area under the curve; BCS; Biopharmaceutics classification system; BE; Bioequivalence; BP; Blood-to-plasma ratio; CCC; Concordance Correlation Coeffici
IMI - Oral biopharmaceutics tools project - Evaluation of bottom-up PBPK prediction success part 2: An introduction to the simulation exercise and overview of results
Keywords: حجم توزیع; API; Active pharmaceutical ingredient; AUC; Area under the curve; BCS; Biopharmaceutics classification system; BE; Bioequivalence; BP; Blood-to-plasma ratio; CL; Clearance; CL/F; Apparent clearance; Cmax; Maximum concentration; Do; Dose number; fa; Fracti
Is sunitinib a Narrow Therapeutic Index Drug? - A systematic review and in vitro toxicology-analysis of Sunitinib vs. Imatinib in cells from different tissues
Keywords: حجم توزیع; Apoptosis; Drug safety; Imatinib; Narrow Therapeutic Index Drug (NTID); Receptor tyrosine kinase (RTK); Sunitinib; Toxicity; Tyrosine kinase inhibitor (TKI); Cell viability; ALL; acute lymphoblastic leukemia; AUC; area under the curve; b.i.d.; twice daily
Lipophilicity and biomimetic properties measured by HPLC to support drug discovery
Keywords: حجم توزیع; Lipophilicity; Biomimetic HPLC; HSA binding; IAM binding; Drug efficiency; Volume of distribution;
Andrographis paniculata: Dissolution investigation and pharmacokinetic studies of four major active diterpenoids after multiple oral dose administration in healthy Thai volunteers
Keywords: حجم توزیع; 1; andrographolide; 2; 14-deoxy-11, 12-didehydroandrographolide; 3; neoandrographolide; 4; 14-deoxyandrographolide; AUC; area under plasma concentration-time curve; Cmax; maximum concentration; Cl; clearance; EDTA; ethylenediaminetetraacetic acid; F; bioa
Slow R-warfarin 7-hydroxylation mediated by P450 2C19 genetic variants in cynomolgus monkeys in vivo
Keywords: حجم توزیع; AUC; area under the plasma concentration vs. time curve; CL; total body clearance; P450; general term for cytochrome P450 (EC 1.14.14.1); t1/2; elimination half-life; V; volume of distribution; Cynomolgus monkey; CYP2C19; Genotyping; Stereoselectivity; S-
The influence of the body mass index (BMI) on the volume of distribution of ethanol
Keywords: حجم توزیع; Alcohol; Body mass index; Ethanol; Pharmacokinetics; Volume of distribution; Widmark factor
Vertical allometry: Fact or fiction?
Keywords: حجم توزیع; Vertical allometry; Allometric scaling; Clearance; Volume of distribution;
Inhibitory activity of sesaminol and sesaminol triglycoside on cytochrome P450 enzymes and their pharmacokinetics in rats
Keywords: حجم توزیع; STG; sesaminol triglycoside; CYPs; cytochrome P450; Cmax; the maximum plasma concentration; Tmax; the time to reach maximum plasma concentration; t1/2; the half-lives; AUC; the area under the drug concentration-time curve; Cl; clearance; Vd; volume of d
Antenatal Pharmacokinetics and Placental Transfer of N-Acetylcysteine in Chorioamnionitis for Fetal Neuroprotection
Keywords: حجم توزیع; C:M; Cord/maternal; CA; Chorioamnionitis; CL; Clearance; GA; Gestational age; GSH; Glutathione; IV; Intravenous; NAC; N-acetylcysteine; PK; Pharmacokinetic; t1/2; Terminal elimination half-life; Vd; Volume of distribution;
Preclinical pharmacokinetic and toxicological evaluation of MIF-1 peptidomimetic, PAOPA: Examining the pharmacology of a selective dopamine D2 receptor allosteric modulator for the treatment of schizophrenia
Keywords: حجم توزیع; 5-HT2; 5-hydroxytryptamine; 6-OHDA; 6-hydroxydopamine; AM; allosteric modulator; AUC; area under curve; AUCINF; area under curve extrapolated to infinity; AUClast; area under curve from dosing to observation; AUMC; area under first moment curve; CL; total
Development and application of simple pharmacokinetic models to study human exposure to di-n-butyl phthalate (DnBP) and diisobutyl phthalate (DiBP)
Keywords: حجم توزیع; 2OH-MiBP; 2OH-mono-iso-butyl phthalate; 3OH-MiBP; 3OH-mono-iso-butyl phthalate; 3OH-MnBP; 3OH-mono-n-butyl phthalate; 4OH-MnBP; 4OH-mono-n-butylphthalate; AGD; anogenital distance; DEHP; di-2-ethylhexyl phthalate; DiBP; diisobutyl phthalate; DnBP; di-n-bu
Perspectives on a pharmacokinetics legend: C versus T (contributions over time)
Keywords: حجم توزیع; Pharmaceutical sciences; pharmacokinetics; Leslie Z. Benet; volume of distribution; clearance concepts; biopharmaceutics classification system; uremic toxins; half-life; Ebert prize; Higuchi Research prize; American Pharmaceutical Association; American As
Convection enhanced delivery of different molecular weight tracers of gadolinium-tagged polylysine
Keywords: حجم توزیع; Magnetic resonance imaging; Imaging tracers; Volume of distribution; Parkinson's disease
Tissue-to-blood distribution coefficients in the rat: Utility for estimation of the volume of distribution in man
Keywords: حجم توزیع; Tissue-to-blood partition coefficient; In vitro and in vivo methods for drug distribution; Trend analysis of distribution; Animal extrapolations; Volume of distribution
The organization and composition of body fluids
Keywords: حجم توزیع; Extracellular fluid; fluid balance; fluid compartments; intracellular fluid; ion composition; sodium homeostasis; volume homeostasis; volume of distribution
5-HT2A receptor antagonist M100907 reduces serotonin synthesis: An autoradiographic study
Keywords: حجم توزیع; 5-HT; 5-hydroxytryptamine; α-MTrp; α-methyl-l-tryptophan; SSRI; selective serotonin reuptake inhibitor; M100907; R(+)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenylethyl)]-4-piperidine-methanol; OBX; olfactory bulbectomized rats; DV*; volume of distri
Intravenous Dosing Conditions May Affect Systemic Clearance for Highly Lipophilic Drugs: Implications for Lymphatic Transport and Absolute Bioavailability Studies
Keywords: حجم توزیع; lymphatic transport; lymph; lipophilic drug; lipid; lipoproteins; intravenous; formulation; clearance; bioavailability; volume of distribution
Drug use and nephrotoxicity in the intensive care unit
Keywords: حجم توزیع; acute kidney injury; chronic kidney disease; drugs; intensive care unit; pharmacokinetics; volume of distribution;
Optimization of a Parallel Artificial Membrane Permeability Assay for the Fast and Simultaneous Prediction of Human Intestinal Absorption and Plasma Protein Binding of Drug Candidates: Application to Dibenz[b,f]azepine-5-Carboxamide Derivatives
Keywords: حجم توزیع; Biopharmaceutics Classification System; dibenz[b; f]azepine-5-carboxamide derivatives; high-throughput technology; intestinal absorption; parallel artificial membrane permeability assay; permeability; protein binding; transcellular transport; volume of di
Advancing Prediction of Tissue Distribution and Volume of Distribution of Highly Lipophilic Compounds from a Simplified Tissue-Composition-Based Model as a Mechanistic Animal Alternative Method
Keywords: حجم توزیع; animal alternative; ADME; disposition; distribution; volume of distribution; pharmacokinetics; protein binding; unbound fraction; PBPK; first-time-in-human;
High-performance liquid chromatography assay of gnetol in rat serum and application to pre-clinical pharmacokinetic studies
Keywords: حجم توزیع; HPLC; high-performance liquid chromatography; UV; ultraviolet; PAR; peak area ratio; R.S.D.; relative standard deviation; S.E.M.; standard error of the mean; DMSO; dimethyl sulfoxide; LOQ; limit of quantitation; Vd; volume of distribution; Gnetol; Reverse
Discovery, synthesis and SAR of azinyl- and azolylbenzamides antagonists of the P2X7 receptor
Keywords: حجم توزیع; P2X7 antagonists; Parallel medicinal chemistry; Rheumatoid arthritis; Volume of distribution; Oral bioavailability;
Pharmacokinetics of Levetiracetam in Neonates with Seizures
Keywords: حجم توزیع; GFR; Glomerular filtration rate; Vd; Volume of distribution;
Toxicokinetics, including saturable protein binding, of 4-chloro-2-methyl phenoxyacetic acid (MCPA) in patients with acute poisoning
Keywords: حجم توزیع; MCPA; 4-chloro-2-methylphenoxyacetic acid; 2,4-D; 2,4-dichlorophenoxyacetic acid; t1/2; apparent elimination half-life; Cu; free (unbound) plasma concentration; Kdi; affinity constant of binding at the ith site; Bmaxi; maximum density (concentration of sa
Use of unbound volumes of drug distribution in pharmacokinetic calculations
Keywords: حجم توزیع; Volume of distribution; Plasma protein binding; Displacement of drug from plasma proteins; Pharmacokinetic modeling